Pharmacological Evaluation of Plant Derived Flavonoid Hesperidin

The study demonstrated that many of the symptoms that characterized some forms of depression in humans were presented in experimental animals following endotoxin (LPS) administration. These symptoms included reduced social, exploratory and locomotor activity. Moreover, chronic pre-treatment with hesperidin attenuated or completely abolished these symptoms. This study also provided a leading experimentation concerning the protective in vivo effects of hesperidin on various systems associated with oxidative stress in endotoxemic rat brain and, that may provide excellent protection against several neurodegenerative diseases among other disorders associated with oxidative stress. Our data support the potential value of these agents for the therapy of septic shock. The current report offers compelling, but perhaps not conclusive, arguments for an association between behavioral and brain anatomical changes induced by LPS and its attenuation by hesperidin.