Pod klinick\u00fdm znakem hyperpigmentace neboli \u201ecaf\u00e9 au lait\u201c (CAL), ploch\u00fdch k\u00e1vov\u00fdch skvrn na k\u016f\u017ei, se skr\u00fdvaj\u00ed mnoh\u00e9 syndromy s multiorg\u00e1nov\u00fdm po\u0161kozen\u00edm a malignitami. Precizn\u00ed klinick\u00e1 diagnostika na z\u00e1klad\u011b typu ko\u017en\u00edch morf, asociovan\u00fdch p\u0159\u00edznak\u016f a jin\u00fdch charakteristik, proveden\u00e1 ve spolupr\u00e1ci s dermatology a dal\u0161\u00edmi odborn\u00edky, umo\u017e\u0148uje v\u010dasn\u00e9 rozpozn\u00e1n\u00ed geneticky podm\u00edn\u011bn\u00e9ho onemocn\u011bn\u00ed. V publikaci se auto\u0159i cht\u011bj\u00ed pod\u011blit o nejnov\u011bj\u0161\u00ed poznatky z literatury, stejn\u011b jako o vlastn\u00ed klinick\u00e9 zku\u0161enosti v r\u00e1mci diferenci\u00e1ln\u00ed diagnostiky, genetick\u00e9 diagnostiky a managementu nej\u010dast\u011bj\u0161\u00edho onemocn\u011bn\u00ed s CAL \u2013 neurofibromat\u00f3zy typu I.
\nVelk\u00e1 \u010d\u00e1st monografie je v\u011bnov\u00e1na m\u00e9n\u011b \u010dast\u00fdm situac\u00edm p\u0159i syndromech s CAL velmi podobn\u00fdch NF1 \u2013 Legiusovu \u010di Noonanov\u00e9 syndromu anebo syndromu konstitu\u010dn\u00edho deficitu mismatch opravn\u00e9ho syst\u00e9mu. Kniha poskytuje ucelen\u00fd a aktu\u00e1ln\u00ed p\u0159ehled \u010dast\u00fdch i vz\u00e1cn\u00fdch multisyst\u00e9mov\u00fdch genetick\u00fdch onemocn\u011bn\u00ed s v\u00fdskytem hyperpigmentac\u00ed, a to bez sou\u010dasn\u00e9ho v\u00fdskytu malignity i s jej\u00edm rizikem.
\nKa\u017ed\u00e1 choroba je podrobn\u011b charakterizov\u00e1na klinicky a geneticky s aktu\u00e1ln\u00edm postojem k jej\u00edmu managementu a l\u00e9\u010db\u011b. Uvedeny jsou i kontakty na aktu\u00e1ln\u00ed internetov\u00e9 zdroje, v\u011bdeck\u00e9 projekty a sv\u00e9pomocn\u00e9 skupiny.<\/p>\n","protected":false},"excerpt":{"rendered":"
Pod klinick\u00fdm znakem hyperpigmentace neboli \u201ecaf\u00e9 au lait\u201c (CAL), ploch\u00fdch k\u00e1vov\u00fdch skvrn na k\u016f\u017ei, se skr\u00fdvaj\u00ed mnoh\u00e9 syndromy s multiorg\u00e1nov\u00fdm po\u0161kozen\u00edm a malignitami. Precizn\u00ed klinick\u00e1 diagnostika na z\u00e1klad\u011b typu ko\u017en\u00edch […]<\/p>\n","protected":false},"featured_media":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_EventAllDay":false,"_EventTimezone":"","_EventStartDate":"","_EventEndDate":"","_EventStartDateUTC":"","_EventEndDateUTC":"","_EventShowMap":false,"_EventShowMapLink":false,"_EventURL":"","_EventCost":"","_EventCostDescription":"","_EventCurrencySymbol":"","_EventCurrencyCode":"","_EventCurrencyPosition":"","_EventDateTimeSeparator":"","_EventTimeRangeSeparator":"","_EventOrganizerID":[],"_EventVenueID":[],"_OrganizerEmail":"","_OrganizerPhone":"","_OrganizerWebsite":"","_VenueAddress":"","_VenueCity":"","_VenueCountry":"","_VenueProvince":"","_VenueState":"","_VenueZip":"","_VenuePhone":"","_VenueURL":"","_VenueStateProvince":"","_VenueLat":"","_VenueLng":"","_VenueShowMap":false,"_VenueShowMapLink":false,"twitterCardType":"","cardImageID":0,"cardImage":"","cardTitle":"","cardDesc":"","cardImageAlt":"","cardPlayer":"","cardPlayerWidth":0,"cardPlayerHeight":0,"cardPlayerStream":"","cardPlayerCodec":""},"product_cat":[],"product_tag":[],"class_list":["post-66531","product","type-product","status-publish","hentry"],"acf":{"description":"Pod klinick\u00fdm znakem hyperpigmentace neboli \u201ecaf\u00e9 au lait\u201c (CAL), ploch\u00fdch k\u00e1vov\u00fdch skvrn na k\u016f\u017ei, se skr\u00fdvaj\u00ed mnoh\u00e9 syndromy s multiorg\u00e1nov\u00fdm po\u0161kozen\u00edm a malignitami. Precizn\u00ed klinick\u00e1 diagnostika na z\u00e1klad\u011b typu ko\u017en\u00edch morf, asociovan\u00fdch p\u0159\u00edznak\u016f a jin\u00fdch charakteristik, proveden\u00e1 ve spolupr\u00e1ci s dermatology a dal\u0161\u00edmi odborn\u00edky, umo\u017e\u0148uje v\u010dasn\u00e9 rozpozn\u00e1n\u00ed geneticky podm\u00edn\u011bn\u00e9ho onemocn\u011bn\u00ed. V publikaci se auto\u0159i cht\u011bj\u00ed pod\u011blit o nejnov\u011bj\u0161\u00ed poznatky z literatury, stejn\u011b jako o vlastn\u00ed klinick\u00e9 zku\u0161enosti v r\u00e1mci diferenci\u00e1ln\u00ed diagnostiky, genetick\u00e9 diagnostiky a managementu nej\u010dast\u011bj\u0161\u00edho onemocn\u011bn\u00ed s CAL \u2013 neurofibromat\u00f3zy typu I.\nVelk\u00e1 \u010d\u00e1st monografie je v\u011bnov\u00e1na m\u00e9n\u011b \u010dast\u00fdm situac\u00edm p\u0159i syndromech s CAL velmi podobn\u00fdch NF1 \u2013 Legiusovu \u010di Noonanov\u00e9 syndromu anebo syndromu konstitu\u010dn\u00edho deficitu mismatch opravn\u00e9ho syst\u00e9mu. Kniha poskytuje ucelen\u00fd a aktu\u00e1ln\u00ed p\u0159ehled \u010dast\u00fdch i vz\u00e1cn\u00fdch multisyst\u00e9mov\u00fdch genetick\u00fdch onemocn\u011bn\u00ed s v\u00fdskytem hyperpigmentac\u00ed, a to bez sou\u010dasn\u00e9ho v\u00fdskytu malignity i s jej\u00edm rizikem. \nKa\u017ed\u00e1 choroba je podrobn\u011b charakterizov\u00e1na klinicky a geneticky s aktu\u00e1ln\u00edm postojem k jej\u00edmu managementu a l\u00e9\u010db\u011b. Uvedeny jsou i kontakty na aktu\u00e1ln\u00ed internetov\u00e9 zdroje, v\u011bdeck\u00e9 projekty a sv\u00e9pomocn\u00e9 skupiny.","item_id":"LX1581383","productname":"Neurofibromat\u00f3za a in\u00e9 syndromy s \u201ecaf\u00e9 au lait\u201c makulami","product":"Neurofibromat\u00f3za a in\u00e9 syndromy s \u201ecaf\u00e9 au lait\u201c makulami","url":"https:\/\/www.luxor.cz\/v\/1581383\/neurofibromatoza-a-ine-syndromy-scafe-au-lait-makulami","imgurl":"https:\/\/img.luxor.cz\/orig\/produkty\/9788020457417.jpg","price_vat":"313.00","margin":"","vat":"","paramname1":"","paramval1":"","paramname2":"","paramval2":"","paramname3":"","paramval3":"","paramname4":"","paramval4":"","paramname5":"","paramval5":"","paramname6":"","paramval6":"","paramname7":"","paramval7":"","paramname8":"","paramval8":"","paramname9":"","paramval9":"","paramname10":"","paramval10":"","ean":"9788020457417","manufacturer":"Mlad\u00e1 fronta","categorytext":""},"_links":{"self":[{"href":"https:\/\/www.luxor.cz\/blog\/wp-json\/wp\/v2\/product\/66531","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.luxor.cz\/blog\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.luxor.cz\/blog\/wp-json\/wp\/v2\/types\/product"}],"replies":[{"embeddable":true,"href":"https:\/\/www.luxor.cz\/blog\/wp-json\/wp\/v2\/comments?post=66531"}],"wp:attachment":[{"href":"https:\/\/www.luxor.cz\/blog\/wp-json\/wp\/v2\/media?parent=66531"}],"wp:term":[{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.luxor.cz\/blog\/wp-json\/wp\/v2\/product_cat?post=66531"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.luxor.cz\/blog\/wp-json\/wp\/v2\/product_tag?post=66531"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}